I have a similar issue but in my case between KDE and Gnome. KDE is much cleaner by display the fonts as Gnome. But I prefer using Gnome, because of the cluttered interface of most KDE applications.
Maybe… If I use the stable version, it works also sometimes with PROTON_USE_WINED3D=1, but has only 2fps. I can remove this parameter with the dev version and have 45fps.
Unfortunately, this version violates the DSGVO by sending telemetry without being asked. This shoots the app directly into out. I hope that the developers have an insight here and remove this function as soon as possible.